Antiparasitic artemisinin derivatives (endoperoxides)

US6984640B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Richard K. Haynes · Kowloon, CN
• William Wai-Lun Lam · Kowloon, CN
• Ho-Wai Chan · Tsuen Wan, CN
• Hing-Wo Tsang · Sha Tin, CN
• Man-Ki Cheung · Tseung Kwan O, CN
• Gisela Greif · Bad Honnef, DE
• Gabriele Schmuck · Wuppertal, DE
• Arnd Voerste

Key dates

• Filing date: Jul 14, 1999
• Grant date: Jan 10, 2006
• Expiry date: Jul 14, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substituted deriviatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.