Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein

US6984645B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• David R. Magnin · Hillsborough Township, US
• Richard B. Sulsky · Somerville, US
• Jeffrey A. Robl · Newtown, US
• Thomas J. Caulfield · Lawrenceville, US
• Rex A. Parker · Titusville, US

Key dates

• Filing date: Nov 15, 2002
• Grant date: Jan 10, 2006
• Expiry date: Jul 6, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.