Pyridine derivatives

US6984649B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Toshiki Murata · Nara, JP
• Masaomi Umeda · Nara, JP
• Sachiko Sakakibara · Nara, JP
• Takashi Yoshino · Nara, JP
• Hiroki Sato · Nara, JP
• Tsutomu Masuda · Amagasaki, JP
• Yuji Koriyama · Kusatsu, JP
• Mitsuyuki Shimada · Nara, JP
• Takuya Shintani · Kyoto, JP
• Hiroshi Kadono · Kasai, JP
• Timothy B. Lowinger · Carlisle, US
• Karl Ziegelbauer · Wuppertal, DE
• Kinji Fuchikami · Kyoto, JP
• Hiroshi Komura · Nara, JP

Key dates

• Filing date: Mar 28, 2003
• Grant date: Jan 10, 2006
• Expiry date: Mar 28, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents 1.2.3.6-tetrahydro-pyridine, or —CR31R32R33 wherein R31 represents H or C1-6 alkyl and R32 and R33 are joined to form a 5-8 membered saturated ring optionally containing up to three heteroatoms; R4 is carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.