Process for making an aldehyde

US6984735B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• John C. McKew · Ames, US
• Steven Y. Tam · Wellesley, US
• Katherine Lin Lee · Newton, US
• Lihren Chen · Cambridge, US
• Paresh Thakker · Boston, US
• Fuk-Wah Sum · Pomona, US
• Mark Behnke · Somerville, US
• Baihua Hu · Audubon, US
• James D. Clark · Acton, US
• Wei Li · Acton, US

Key dates

• Filing date: Nov 26, 2003
• Grant date: Jan 10, 2006
• Expiry date: Dec 13, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.