Transgenic non-human mammals producing a cholinesterase in their milk
US6987211B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 12, 1999 |
| Grant date | Jan 17, 2006 |
| Priority date | — |
| Expiry date | May 12, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0356
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been identified in various malignant tumor cells. In a further aspect, the invention relates to a transgenic animal assay system for evaluating efficacy of drugs against cholinergic proteins, prior to or in the course of therapeutic treatment. Transgenic animals, preferably developing tadpole of Xenopus or mice which express human AChE, are used. The transgenic animal assay system is also useful for evaluating the toxicity of substances which potentially block human AChE (e.g. organophosphorous compounds).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.