Radiation sensitive liposomes
US6989153B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 30, 2000 |
| Grant date | Jan 24, 2006 |
| Priority date | — |
| Expiry date | Nov 30, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.