Progenitor cell preservation factors and methods for and products of their use

US6991794B1 · kind B1 · utility

Assignees

• ImClone Systems Incorporated · US
• The Regents of the University of California · US

Inventors

• M. Colucci · Dugenta, IT
• Maarten Chrispeels · Village of La Jolla, US
• Jeffrey Moore · Kennebunkport, US

Key dates

• Filing date: Dec 30, 1999
• Grant date: Jan 31, 2006
• Expiry date: Dec 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/59
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are the FRIL family of progenitor cell preservation factors and nucleic acids encoding the same. FRIL family members preserve progenitor cells both in vivo and ex vivo. FRIL family members find use as therapeutics for alleviating and/or reducing the hematopoietic progenitor cell-depleting activity of many cancer therapeutics. FRIL family members are also useful for isolating rare, primitive progenitor cells.