Melphalan derivatives and their use as cancer chemotherapeutic drugs

US6992207B2 · kind B2 · utility

Assignee

• Oncopeptides AB · SE

Inventors

• Rolf Lewensohn · Danderyd, SE
• Joakim Gullbo · Uppsala, SE
• Rolf Larsson · Uppsala, SE
• Hans Ehrsson · Stockholm, SE
• Kristina Luthman · Gothenburg, SE

Key dates

• Filing date: Jun 11, 2001
• Grant date: Jan 31, 2006
• Expiry date: Jun 25, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a pharmaceutical composition comprising the alkylating peptides of the invention.