Substituted alkylamine derivatives and methods of use

US6995162B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Guoqing Chen · Boise, US
• Jeffrey Adams · Thousand Oaks, US
• Jean E. Bemis · Arlington, US
• Shon Booker · Thousand Oaks, US
• Guolin Cai · Guilford, US
• Lucian Di Pietro · Gloucester, US
• Celia Dominguez · Los Angeles, US
• Daniel Elbaum · Newton, US
• Julie Germain · Medford, US
• Stephanie Geuns-Meyer · Medford, US
• Michael Handley · Greenbrae, US
• Qi Huang · Moorpark, US
• Joseph L. Kim · Wayland, US
• Tae-Seong Kim · Yongin-si, KR
• Alexander Kiselyov · Jersey City, US
• Xiaohu Ouyang · Rosemead, US
• Vinod F. Patel · Acton, US
• Leon M. Smith, II · Raritan, US
• Markian Stec · Thousand Oaks, US
• Andrew Tasker · Simi Valley, US
• Ning Xi · Newbury Park, US
• Shimin Xu · Beijing, CN
• Chester Chenguang Yuan · Newbury Park, US
• Michael Croghan · Thousand Oaks, US

Key dates

• Filing date: Jan 10, 2002
• Grant date: Feb 7, 2006
• Expiry date: Jul 10, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.