Modulators of the glucocorticoid receptor and method

US6995181B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Wayne Vaccaro · Yardley, US
• Bingwei Yang · Montgomery, US
• Soong-Hoon Kim · Titusville, US
• Tram N. Huynh · Pennington, US
• David R. Tortolani · Skillman, US
• Kenneth J. Leavitt · Mount Laurel, US
• Wenying Li · Tangxia, CN
• Arthur M. P. Doweyko · Long Valley, US
• Xiao-Tao Chen · New York, US
• Lidia M. Doweyko · Vero Beach, US

Key dates

• Filing date: Jul 17, 2003
• Grant date: Feb 7, 2006
• Expiry date: Aug 22, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure where Z is CONR1R2 or CH2NR1R2 and where R, Ra, Rb, Rc, Rd, Z, A and B are defined herein.