Treatment of inflammatory disease
US6995240B1 · kind B1 · utility
8Cited by
2References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 8, 1999 |
| Grant date | Feb 7, 2006 |
| Priority date | — |
| Expiry date | Oct 8, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The immunoglobulin heavy chain binding protein BiP(GRP78), or a fragment thereof, provides a reagent for indicating the presence of rheumatoid arthritis (RA). The protein used is a recombinant BiP(GRP78) having a defined sequence. A prognostic and/or diagnostic test for RA may be an ELISA or a Western Blot that utilizes the BiP(GRP78) protein or a fragment thereof. Also disclosed are a method of testing for RA using BiP(GRP78) or a cDNA sequence coding therefor. Further disclosed is a method of treating RA by the BiP(GRP78) protein or corresponding cDNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.