Cyanine dyes

US6995274B2 · kind B2 · utility

Assignee

• LI-COR, Inc. · US

Inventors

• Ananda G. Lugade · Austin, US
• Narasimhachari Narayanan · Lincoln, US
• Daniel R. Draney · Norwalk, US

Key dates

• Filing date: Jan 28, 2003
• Grant date: Feb 7, 2006
• Expiry date: Jan 28, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/533
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A compound of the formula (I) wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1–R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3−Cat+, wherein Cat+ is a cation and at least one of R1–R5 is SO3−Cat+; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9–R12 and R14–R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH, R21OR22, R21SR22, or R21COOR22 wherein R21 is a bond or alkylene and R22 is alkyl, or optionally R11 and R12 together with the atoms to which they are bonded form an aromatic ring, …