Process for preparing simvastatin having controlled ranges of simvastatin dimer content
US6995277B2 · kind B2 · utility
2Cited by
4References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 11, 2004 |
| Grant date | Feb 7, 2006 |
| Priority date | — |
| Expiry date | May 14, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4% wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.