Targeted retrograde gene delivery for neuronal protection
US6998118B2 · kind B2 · utility
7Cited by
4References
6Claims
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Key dates
| Filing date | Dec 21, 2001 |
| Grant date | Feb 14, 2006 |
| Priority date | — |
| Expiry date | Feb 25, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are disclosed for transducing neurons with heterologous genes using retrograde viral transport. The methods disclosed employ substantially non-toxic vectors, such as adeno-associated virus vectors, that are capable of retrograde axonal transport to introduce and express genes in the neurons. This method has applications in the mapping of neural pathways, in stimulating or inhibiting the growth of neurons, and in the treatment of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.