Screen for selective inhibitors or activators of Smad protein function
US6998240B2 · kind B2 · utility
2Cited by
1References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 11, 2002 |
| Grant date | Feb 14, 2006 |
| Priority date | — |
| Expiry date | Dec 8, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4703
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of screening for selective inhibitors or activators Smad protein function is disclosed. In one embodiment, the invention comprises the steps of (a) obtaining a phosphorylated Smad protein or protein complex, (b) allowing the phosphorylated Smad protein or complex to interact with a target protein or peptide in the presence of a test compound, and (c) analyzing the binding of the phosphorylated Smad complex or protein and the target protein or peptide, wherein a perturbation of binding indicates that the test compound is an inhibitor or activator of Smad-target protein interaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.