Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US6998247B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2003 |
| Grant date | Feb 14, 2006 |
| Priority date | — |
| Expiry date | May 22, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/49
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variation that are built into the calibration model. An additional method uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The methods provide a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.