Process for the preparation of sulphonamide-substituted imidazotriazinones

US6998483B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Marc Nowakowski · Wuppertal, DE
• Reinhold Gehring · Wuppertal, DE
• Werner Heilmann · Wuppertal, DE
• Karl-Heinz Wahl · Erkelenz, DE

Key dates

• Filing date: May 5, 2005
• Grant date: Feb 14, 2006
• Expiry date: May 5, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.