Purification of red blood cells by separation and diafiltration
US7001715B2 · kind B2 · utility
7Cited by
29References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2002 |
| Grant date | Feb 21, 2006 |
| Priority date | — |
| Expiry date | Apr 8, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Red blood cells are purified by separating whole blood, such as by centrifugation, to form a red blood cell fraction and a liquid fraction. The whole blood can be defibrinated or treated to prevent coagulation prior to separation. Preferably, the whole blood is bovine blood. The red blood cell fraction is then diafiltered to purify the red blood cells. The purified red blood cells can then be lysed to form a lysate of purified red blood cells. The purified red blood cells and the lysate of purified red blood cells are suitable for use in producing hemoglobin blood substitute.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.