Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination

US7001890B1 · kind B1 · utility

Assignee

• COLEY PHARMACEUTICAL GMBH · DE

Inventors

• Hermann Wagner · Unterschleißheim, DE
• Grayson B. Lipford · Watertown, US
• Klaus Heeg · Marburg, DE

Key dates

• Filing date: Jan 23, 1998
• Grant date: Feb 21, 2006
• Expiry date: Jan 23, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.