Tubulin binding agents and corresponding prodrug constructs

US7001926B2 · kind B2 · utility

Assignees

• OXiGENE, Inc. · US
• Baylor University · US

Inventors

• Kevin G. Pinney · Woodway, US
• Vani P. Mocharla · Los Angeles, US
• Zhi Chen · Seattle, US
• Mallinath Hadimani · Waco, US
• Jimmy Kessler · Saginaw, US
• James M. Dorsey · Havertown, US
• Klaus Edvardsen · Klampenborg, DK
• David Chaplin · Aston Rowant, GB
• Joseph Prezioso · Boston, US
• Anjan Ghatak · Salt Lake City, US

Key dates

• Filing date: Apr 1, 2003
• Grant date: Feb 21, 2006
• Expiry date: Jun 2, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.