Process for the preparation on enantiomerically enriched compounds

US7002037B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Kjell Andersson · Bissenkamp, SE
• Alan Fischer · Biberstein, CH
• Panagiotis Ioannidis · Skattkärr, SE
• Magnus Larsson · Sollentuna, SE
• Maria Larsson · Malung, SE
• Sivaprasad Sivadasan · Malung, SE

Key dates

• Filing date: Nov 29, 2000
• Grant date: Feb 21, 2006
• Expiry date: May 31, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the insulin resistance syndrome (IRS). It is such a process that the present inventions sets out to define, and more particularly for the preparation of the (S)-enantioner of certain 2-ethoxy-3-(4-hydroxyphenyl)propanoic acids and derivatives thereof.