Compositions that bind antiterminator RNA and assay for screening such compositions
US7005441B2 · kind B2 · utility
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Key dates
| Filing date | Aug 23, 2002 |
| Grant date | Feb 28, 2006 |
| Priority date | — |
| Expiry date | Aug 23, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds that are selective binding agents specific for RNA secondary and tertiary structures and a fluorescence assay for detecting the binding of small molecules to T-box antiterminator model mRNAs. The compounds include novel tri-substituted oxazolidinones and amino alcohols. The assay provides fluorescently labeled model mRNAs that include conserved sequence information typical of antiterminator bulge regions found in the mRNA of T-box gene regulatory systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.