Polymeric drug formulations
US7005454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1999 |
| Grant date | Feb 28, 2006 |
| Priority date | — |
| Expiry date | May 1, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.