Method for determining analyte concentration using periodic temperature modulation and phase detection
US7006857B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 28, 2003 |
| Grant date | Feb 28, 2006 |
| Priority date | — |
| Expiry date | Jul 21, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/35
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.