Powder formation by atmospheric spray-freeze drying
US7007406B2 · kind B2 · utility
53Cited by
5References
14Claims
0Family size
Inventors
Key dates
| Filing date | Jan 23, 2004 |
| Grant date | Mar 7, 2006 |
| Priority date | — |
| Expiry date | Jan 23, 2024 |
Classification
- Technology area (CPC F)Mechanical Engineering; Lighting; Heating
- CPC primaryF26B13/30
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.