Recombinant constructs of Borrelia burgdorferi

US7008625B2 · kind B2 · utility

Assignee

• Research Foundation for the State University of New York York · US

Inventors

• Raymond J. Dattwyler · Setauket, US
• Maria Gomes-Solecki · Memphis, US
• Benjamin J. Luft · East Setauket, US
• John J. Dunn · Bellport, US

Key dates

• Filing date: Feb 18, 2003
• Grant date: Mar 7, 2006
• Expiry date: Feb 18, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.