Hydrogels for orthopedic repair

US7008635B1 · kind B1 · utility

Assignee

• Genzyme Corporation · US

Inventors

• Arthur J. Coury · Windom, US
• Stephen D. Goodrich · Woburn, US
• Hildegard Kramer · Westport, US
• Luis Z. Avila · Arlington, US
• John Traverse · Somerville, US
• Peter Jarrett · Sudbury, US

Key dates

• Filing date: Sep 8, 2000
• Grant date: Mar 7, 2006
• Expiry date: Sep 8, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.