Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
US7008776B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 26, 1999 |
| Grant date | Mar 7, 2006 |
| Priority date | — |
| Expiry date | Mar 26, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/918
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid; a neutralizing antibody; an intracellular binding protein; an inhibitor which inhibits the enzymatic activity of LIPG polypeptide; an inhibitor which inhibits the expression of LIPG gene; a ribozyme; an LIPG polypeptide; an enhancer which increases the enzymatic activity of LIPG polypeptide; or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions.In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.