Non-infectious, non-replicating, immunogenic human immunodeficiency virus-like particles
US7008784B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1999 |
| Grant date | Mar 7, 2006 |
| Priority date | — |
| Expiry date | Sep 3, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/924
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed toward methods for the production of non-infectious, replication-deficient, immunogenic human immunodeficiency virus (HIV)-like particles. These particles are prepared from a recombinant expression vector comprising a heterologous promoter operatively connected to a DNA molecule comprising a modified HIV genome devoid of the long terminal repeat (LTR) regulatory regions but containing at least the gag and pol genes in their natural genomic arrangement. This vector is introduced into mammalian cells to produce the particles of interest. These particles should prove useful in a number of diagnostic, virologic, and immunologic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.