Patent · US Expired

Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity

US7009036B2 · kind B2 · utility

0Cited by

1References

1Claims

0Family size

Assignee

Provincia Italiana della Congregazione dei Figli dell'Immacolata Concezione-Istituto Dermopatico dell'Immacolata · IT

Inventors

Antonio Facchiano · Roma, IT
Francesco Facchiano · Roma, IT
Angelo Facchiano · Napoli, IT

Key dates

Filing date	Feb 20, 2002
Grant date	Mar 7, 2006
Priority date	—
Expiry date	Jan 4, 2023

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.