Cocaine receptor binding ligands

US7011813B2 · kind B2 · utility

Assignee

• Research Triangle Institute · US

Inventors

• Michael J. Kuhar · Baltimore, US
• Frank Ivy Carroll · Durham, US
• John W. Boja · Baltimore, US
• Anita H. Lewin · Chapel Hill, US
• Philip Abraham · Cary, US

Key dates

• Filing date: May 28, 2002
• Grant date: Mar 14, 2006
• Expiry date: Feb 10, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.