Heterologous production of polyketides
US7011959B1 · kind B1 · utility
5Cited by
5References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 27, 2000 |
| Grant date | Mar 14, 2006 |
| Priority date | — |
| Expiry date | Oct 27, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/62
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-type E. coli host cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.