Anticancer agents based on prevention of protein prenylation
US7012097B2 · kind B2 · utility
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Key dates
| Filing date | May 14, 2003 |
| Grant date | Mar 14, 2006 |
| Priority date | — |
| Expiry date | May 24, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. α-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.