Patent · US Expired

Method for enhancing long-term memory in a subject and uses thereof

US7015190B1 · kind B1 · utility

2Cited by

0References

5Claims

0Family size

Assignee

The Trustees of Columbia University in the City of New York · US

Inventors

Dusan Bartsch · Heidelberg, DE
Eric R. Kandel · Yonkers, US
Mirella Ghirardi · Torino, IT

Key dates

Filing date	Jun 3, 1996
Grant date	Mar 21, 2006
Priority date	—
Expiry date	Jun 3, 2016

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.