Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

US7015226B2 · kind B2 · utility

Assignee

• Neurocrine Biosciences, Inc. · US

Inventors

• Charles Huang · San Diego, US
• Chen Chen · San Diego, US
• Yongsheng Chen · Shanghai, CN
• Zhiqiang Guo · San Diego, US
• Warren Wade · San Diego, US
• Martin Rowbottom · San Diego, US
• Jaimie Karyn Rueter · San Diego, US

Key dates

• Filing date: Jul 6, 2004
• Grant date: Mar 21, 2006
• Expiry date: Jul 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.