Stabilization of quinapril using magnesium oxide
US7015232B2 · kind B2 · utility
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11References
2Claims
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Key dates
| Filing date | Apr 22, 2002 |
| Grant date | Mar 21, 2006 |
| Priority date | — |
| Expiry date | Apr 22, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1611
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms of degradation when prepared in a pharmaceutical composition consisting essentially of magnesium oxide as the stabilizing agent. The presence of magnesium oxide also lends itself to favorable processing conditions during the manufacture of ACE inhibitor-containing compositions, especially processing by wet granulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.