Vaccine against Gram-negative bacterial infections

US7018636B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Apurba Bhattacharjee · Kensington, US
• Alan Cross · Chevy Chase Section Five, US
• Jerald C. Sadoff · Washington, US
• Wendell D. Zollinger · Silver Spring, US

Key dates

• Filing date: Jun 30, 1997
• Grant date: Mar 28, 2006
• Expiry date: Jun 30, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.