Human N-type calcium channel isoform and uses thereof
US7018832B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2001 |
| Grant date | Mar 28, 2006 |
| Priority date | — |
| Expiry date | Apr 30, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention pertains to a human N-type calcium channel isoform, hα1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human hα1B+SFVG channel. Also included are human N-type calcium channel hα1B+SFVG subunit inhibitors which inhibit human N-type calcium channel hα1B+SFVG subunit activity by inhibiting the expression or function of human N-type calcium channel hα1B+SFVG subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.