Recombinant, biologically active human zona pellucida protein 3 (HZP3) to test male fertility
US7019114B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Feb 19, 1999 |
| Grant date | Mar 28, 2006 |
| Priority date | — |
| Expiry date | Feb 19, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/827
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to methods for producing recombinant human zona pellucida protein (“rhZP3”) and glycosylated peptide having biological activity of binding to human spermatozoa. A human ovarian cell line is used to produce rhZP3 having a glycosylation pattern required for full biological activity. Methods of determining useful peptides with binding activity for human sperm and their syntheses, as well as using such peptides and proteins in therapeutics and diagnostics are discussed.
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