Process for making chiral 1,4-disubstituted piperazines
US7019137B2 · kind B2 · utility
2Cited by
2References
11Claims
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Key dates
| Filing date | Mar 10, 2003 |
| Grant date | Mar 28, 2006 |
| Priority date | — |
| Expiry date | Oct 26, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
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