Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester
US7019162B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 25, 2001 |
| Grant date | Mar 28, 2006 |
| Priority date | — |
| Expiry date | Dec 25, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/307
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.