Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
US7022319B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 8, 1997 |
| Grant date | Apr 4, 2006 |
| Priority date | — |
| Expiry date | Sep 8, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/13043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral infections such as HIV infections and bacterial and fungal infections. In particular the present invention relates to retroviral vectors. Furthermore, the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.