Mutations in human MLH1 and human MSH2 genes useful in diagnosing colorectal cancer
US7022472B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Oct 22, 1999 |
| Grant date | Apr 4, 2006 |
| Priority date | — |
| Expiry date | Oct 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Variant human MLH1 and MSH2 genes are provided. Methods of using these variant genes to diagnose hereditary non-polyposis colorectal cancer (HNPCC) and/or determine a patient's susceptibility to developing HNPCC are also provided. Methods and compositions for identifying new variant MLH1 of MSH2 genes are also provided. In addition, experimental models for hereditary non-polyposis colorectal cancer comprising these variant genes are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.