Myc-binding zinc finger proteins, their preparation and their use

US7022490B1 · kind B1 · utility

Assignee

• Prolifix Limited · GB

Inventors

• Karen Peukert · Lahntal, DE
• Frank Haenel · Jena, DE
• Martin Eilers · Marburg, DE

Key dates

• Filing date: Jul 24, 2000
• Grant date: Apr 4, 2006
• Expiry date: Feb 7, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides assays for determining transcription-modulating substances. The transcription-modulating activity of test compounds is assessed on the basis of their ability to suppress or enhance complex formation between Myc and a novel zinc finger binding protein, Miz-1, or derivatives thereof.