Patent · US Expired

Aryl substituted benzimidazoles and their use as sodium channel blockers

US7022714B2 · kind B2 · utility

44Cited by

4References

43Claims

0Family size

Assignee

Euro-Celtique S.A. · LU

Inventors

Qun Sun · Princeton, US
Xiaoming Zhou · Plainsboro, US
Donald J. Kyle · Yardley, US

Key dates

Filing date	Jul 31, 2003
Grant date	Apr 4, 2006
Priority date	—
Expiry date	Jul 3, 2024

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D235/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention relates aryl substituted benzimidazoles of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1, R2, R10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.