Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against RNA targets and its preparation
US7022839B2 · kind B2 · utility
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Key dates
| Filing date | Dec 5, 2001 |
| Grant date | Apr 4, 2006 |
| Priority date | — |
| Expiry date | Feb 24, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/232
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol, of formula 1, their preparation and their use. Because of their heterodmieric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, they can be effectively used as an antiviral agent, an antibacterial agent or an anticancer drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.