Preparation of substituted aromatic compounds

US7022857B2 · kind B2 · utility

Assignee

• Clariant Corporation · DE

Inventors

• Andreas Meudt · Hofheim, DE
• Michael Erbes · Frankfurt, DE
• Klaus Forstinger · Kelsterbach, DE

Key dates

• Filing date: Oct 2, 2003
• Grant date: Apr 4, 2006
• Expiry date: Dec 19, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/50
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1–C8-alkyl, CH(OC1–C5-alkyl)2, CH(C1–C5-alkyl)(OC1–C5-alkyl), CH2(OC1–C5-alkyl), CH(CH3)(OC1–C5-alkyl), C1–C8-alkoxy, N(C1–C5-alkyl)2, phenyl, substituted phenyl, aryl, heteroaryl, S(C1–C5-alkyl) or a radical Caryl, alkyl, andthe symbols X1 to 5 are each carbon or a maximum of two neighboring X1-5 are nitrogen or X1R1 and X2R2 together are O, NH, N(C1–C5-alkyl), N(C═O—C1–C5-alkyl), N(SiR3)2 or S,or where neighboring radicals R1 to R5 form the following structural unit, where X6 to X9 and R6 to R9 have the same meaning as X1 to X5 and R1 to R5 which comprises reacting chloro- or fluoroaromatics of the formula (I) with carbon electrophiles and lithium metal.