Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof

US7026312B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Rudolf Hurnaus · Großenhain, DE
• Klaus Rudolf · Warthausen, DE
• Stephan Georg Mueller · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Philipp Lustenberger · Warthausen, DE
• Alexander Dreyer · Ochsenhausen, DE
• Kai Gerlach · Biberach, DE
• Marcus Schindler · Schwäbisch Hall, DE
• Kirsten Arndt · Biberach, DE
• Eckhart Bauer · Biberach, DE

Key dates

• Filing date: Mar 13, 2003
• Grant date: Apr 11, 2006
• Expiry date: Oct 1, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.