Therapeutic chromone compounds

US7026314B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Marc Chapdelaine · Wilmington, US
• Timothy Davenport · New Castle, US
• Markus Haeberlein · Wellesley, US
• Carey Horchler · Wayne, US
• John McCauley · Wilmington, US
• Edward Pierson · Wilmington, US
• Daniel Sohn · Gately Drive, SE

Key dates

• Filing date: Jan 15, 2002
• Grant date: Apr 11, 2006
• Expiry date: Jan 15, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.