Patent · US Expired

Pharmaceutical nitrones

US7026338B2 · kind B2 · utility

0Cited by
1References
10Claims
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Assignee

Inventors

Key dates

Filing dateMay 11, 2004
Grant dateApr 11, 2006
Priority date—
Expiry dateJun 6, 2024

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P43/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Pharmaceutical nitrone comprise condensates of an N-hydroxylamine and a physiological aldehyde, providing improved delivery and absorption, enhanced stability and reduced toxicity. Preferred physiological aldehydes are subject to endogenous cellular uptake transport, and include pyridoxal, pyridoxal phosphate, and heme-A. Essentially any physiologically compatible and pharmaceutically active hydroxylamine moiety may be incorporated, such as hydroxylamine moieties of prior pharmaceutical nitrones, and known pharmaceutically active hydroxylamines.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.